Opportunity Information: Apply for RFA HG 22 001
Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional), RFA-HG-22-001, is a National Institutes of Health funding opportunity from the National Human Genome Research Institute (NHGRI) designed to back exceptionally promising Early Stage Investigators who are committed to building long-term, independent research careers in genomics. The emphasis is on enabling early career scientists to pursue innovative, high-impact projects that align with NHGRI's mission, using the NIH R01 research project grant mechanism. Because the announcement is "Clinical Trial Optional," applicants may propose studies that include a clinical trial, but they are not required to do so; non-trial research is equally acceptable as long as it fits the scientific scope.
The scientific scope is broad and intentionally flexible, covering essentially the full range of topics NHGRI supports. This includes foundational genomic sciences (such as methods development, genome function, regulation, and technology platforms), genomic medicine (including translating genomic discoveries into clinical or public health contexts), genomic data science (such as computational genomics, analytics, data integration, and informatics), and research on the ethical, legal, and social implications (ELSI) of genomics. In practice, this means proposals can range from wet-lab and technology development to computational, translational, and policy-relevant work, as long as genomics is central and the project is positioned as a strong step toward an independent research trajectory for the investigator.
Eligibility is expansive across U.S.-based organizations and government entities, reflecting the program's goal of reaching talent across many institutional settings. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education when relevant); for-profit organizations other than small businesses; and small businesses. The opportunity also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, tribal governments other than federally recognized ones, and U.S. territories or possessions. This explicit call-out signals an interest in broad participation, including applicants from institutions that serve groups historically underrepresented in biomedical research.
There are important boundaries around non-U.S. participation. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as applicant organizations, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed when they meet the NIH Grants Policy Statement definition, meaning a U.S. applicant can include certain foreign activities or collaborations as part of the project if they are justified and compliant with NIH policy, even though a foreign organization cannot be the primary applicant.
From an administrative and funding standpoint, this is a discretionary grant opportunity in the health funding category, listed under CFDA 93.172. The original closing date provided for the announcement is February 27, 2024. The award ceiling is listed as $500,000, which typically functions as the maximum amount of funding expected or allowed under the terms of this specific announcement (applicants would still need to follow the FOA's detailed budget rules and NIH policy). The posting indicates the opportunity was created on December 6, 2021. The expected number of awards is not specified in the supplied data, so applicants would generally look to the full FOA or NIH notices for any later updates about anticipated funding levels and award counts.
Overall, the program is best understood as a career-launching R01 opportunity aimed at early stage genomics investigators with standout potential. It supports a wide array of genomics-related research directions, allows but does not require clinical trials, welcomes applications from a broad set of U.S. institutions and organizations (including many minority-serving and community-based entities), and permits foreign components under NIH rules while keeping the applicant organization domestic.Apply for RFA HG 22 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on 2021-12-06.
- Applicants must submit their applications by 2024-02-27. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the "Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)" funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity from the National Human Genome Research Institute (NHGRI) to support exceptionally promising Early Stage Investigators pursuing long-term, independent research careers in genomics. It uses the NIH R01 research project grant mechanism and is intended to enable innovative, high-impact genomics research aligned with NHGRI's mission.
What is the FOA number for this opportunity?
The funding opportunity announcement (FOA) number is RFA-HG-22-001.
Which NIH Institute is sponsoring this opportunity?
The opportunity is sponsored by the National Human Genome Research Institute (NHGRI) within NIH.
What grant mechanism does this program use?
It uses the NIH R01 research project grant mechanism.
Who is this opportunity intended to support?
It is designed to support Early Stage Investigators who are committed to building independent, long-term research careers in genomics and who propose projects positioned as strong steps toward an independent research trajectory.
Is a clinical trial required?
No. The FOA is labeled "Clinical Trial Optional," meaning an application may include a clinical trial, but a clinical trial is not required. Non-trial research is equally acceptable if it fits the scientific scope.
What research areas are supported under this FOA?
The scientific scope is broad and flexible and generally spans the full range of topics NHGRI supports, including foundational genomic sciences, genomic medicine, genomic data science, and research on the ethical, legal, and social implications (ELSI) of genomics.
What are examples of "foundational genomic sciences" topics that could fit this program?
Examples mentioned include methods development, genome function, genome regulation, and technology platforms, as long as genomics is central to the proposed work.
What types of projects fall under "genomic medicine" for this opportunity?
Projects that translate genomic discoveries into clinical or public health contexts are within scope, provided they align with NHGRI's mission and keep genomics as the core focus.
What counts as "genomic data science" in this FOA?
The scope includes computational genomics, analytics, data integration, and informatics approaches that are genomics-centered and aligned with NHGRI priorities.
Does this FOA support ELSI research related to genomics?
Yes. Research on the ethical, legal, and social implications (ELSI) of genomics is explicitly included within the scientific scope.
Is the scope limited to wet-lab genomics research?
No. The scope explicitly accommodates a wide range of approaches, including wet-lab research, technology development, computational work, translational research, and policy-relevant/ELSI research, as long as genomics is central and the project supports the investigator's independent career trajectory.
What is meant by "broad and intentionally flexible" scientific scope?
It means proposals may cover essentially the full spectrum of research areas supported by NHGRI rather than being restricted to a narrow topic area, provided the work is genomics-centered and aligned with NHGRI's mission.
What types of U.S. organizations are eligible to apply?
Eligibility is expansive across U.S.-based organizations and government entities. Eligible applicant types include various levels of government (state, county, city or township, and special districts), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments, tribal organizations that are not federally recognized tribal governments, public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status (with exclusions when institutions of higher education are relevant), for-profit organizations other than small businesses, and small businesses.
Are minority-serving institutions (MSIs) explicitly encouraged or recognized as eligible applicants?
The opportunity explicitly calls out a number of MSI categories as eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible to apply?
Yes. Faith-based or community-based organizations are explicitly highlighted among eligible applicant types.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly highlighted as eligible applicant types.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are explicitly highlighted among eligible applicant types.
Can a non-U.S. (foreign) institution apply as the applicant organization?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as the applicant organization for this opportunity.
Can a U.S. applicant include foreign collaborations or work performed outside the United States?
Yes, foreign components are allowed when they meet the NIH Grants Policy Statement definition. This means a U.S. applicant organization may include certain foreign activities or collaborations if they are justified and compliant with NIH policy, even though the primary applicant organization must be domestic.
Are non-domestic components of U.S. organizations eligible to apply?
No. Non-domestic components of U.S. organizations are not eligible to apply as applicant organizations under this opportunity.
What is the funding category and award type?
The opportunity is described as a discretionary grant in the health funding category.
What is the CFDA number for this program?
The CFDA listing provided is 93.172.
What is the award ceiling for this funding opportunity?
The award ceiling is listed as $500,000. This generally indicates the maximum funding expected or allowed under the announcement, though applicants would still need to follow the FOA's detailed budget rules and NIH policy.
When is the closing date for this opportunity?
The original closing date provided is February 27, 2024.
When was this opportunity created (posted)?
The posting indicates the opportunity was created on December 6, 2021.
How many awards will be made under this FOA?
The expected number of awards is not specified in the provided information. Applicants would typically consult the full FOA text or NIH notices for any updates on anticipated award counts or funding levels.
What is the main goal of this program from a career perspective?
The program is best understood as a career-launching R01 opportunity aimed at early stage genomics investigators with standout potential, supporting research that helps establish a long-term, independent research program.
Does the FOA restrict proposals to a particular kind of genomics (e.g., only technology development or only clinical translation)?
No. The scope includes foundational genomics, translational genomic medicine, computational/data science, and ELSI research. The key is that genomics is central, the work aligns with NHGRI's mission, and the project supports the investigator's path toward independence.
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