Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial optional) | RFA DA 25 020

Opportunity Information: Apply for RFA DA 25 020

The Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial optional) funding opportunity (RFA-DA-25-020) is a discretionary NIH grant aimed at supporting early-stage, practice-focused research to test improved care models that bring HIV services, addiction treatment, and primary care into a more seamless, coordinated system. The central idea is to move beyond fragmented, referral-heavy approaches and instead evaluate enhanced, integrated service designs that can better reach people affected by HIV and substance use, improve engagement and retention in care, and strengthen overall health outcomes through coordinated primary care. Because this is an R34 mechanism and clinical trials are optional, the opportunity is geared toward pilot or developmental testing that can demonstrate feasibility, acceptability, and early signals of impact, often as a precursor to larger-scale effectiveness or implementation studies.

The opportunity is administered by the National Institutes of Health and falls under the Education and Health activity category, with CFDA number 93.279. The funding instrument is a grant, with an award ceiling listed at $450,000. The original application closing date is March 19, 2025. While the listing does not specify the exact number of expected awards, applicants should treat the ceiling and the R34 scope as a strong cue to propose a focused project with clear milestones, realistic recruitment or implementation targets (if applicable), and well-defined evaluation methods that match a developmental research stage rather than a full-scale multi-site trial.

Projects supported under this FOA are expected to test "enhanced models of care" that "optimally integrate" HIV, addiction, and primary care services. In practical terms, this can include models that co-locate services in one setting, tightly coordinate across partnering organizations, or redesign workflows so that patients can receive HIV prevention or treatment, evidence-based substance use services, and routine medical care in a coordinated way. Integrated models may involve shared care plans, interdisciplinary teams, harmonized screening and referral pathways, and approaches that reduce barriers such as transportation challenges, stigma, fragmented records, or inconsistent follow-up. Because the FOA emphasizes testing models, proposals typically need to spell out the intervention or model components, how integration will occur (clinically and operationally), the setting and target population, and how outcomes will be measured to show whether the model is workable and promising.

Eligibility is broad and includes many types of domestic organizations and government entities: state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with or without 501(c)(3) status (excluding higher education institutions where noted); for-profit organizations other than small businesses; small businesses; and other applicant types. The FOA also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This emphasis signals an interest in diverse institutional partners and community-rooted organizations that are well positioned to design and test integrated care approaches in real-world settings, including in underserved communities and jurisdictions disproportionately affected by HIV and substance use.

Overall, this FOA is best viewed as support for rigorous, developmental testing of integrated HIV, addiction, and primary care service models that can inform future scale-up. Competitive applications will typically present a clear integrated-care concept, demonstrate strong partnerships with clinical and community stakeholders, and include an evaluation plan that can credibly assess feasibility and early outcomes within the budget and timeline expected for an R34 project, with the option (but not requirement) to include a clinical trial component if it is appropriate for the model being tested.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Ending the Epidemic: New Models of Integrated HIV/AIDS, Addiction, and Primary Care Services (R34 Clinical Trial optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
• This funding opportunity was created on 2023-07-19.
• Applicants must submit their applications by 2025-03-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $450,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DA 25 020

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