Opportunity Information: Apply for RFA CE 24 012
Rigorous Evaluation of Policy-Level Interventions to Prevent Overdose (R01) is a CDC Injury Center research grant opportunity that funds investigator-initiated studies focused on measuring what overdose-related policies actually do in real-world settings. The core aim is to generate strong, causal evidence on whether specific policies reduce drug use and overdose, while also examining whether those policies narrow or widen existing disparities in health and health care outcomes. This opportunity emphasizes that it is not enough to report overall changes in overdose indicators; applicants are expected to pay close attention to impacts on groups that experience a disproportionate overdose burden or who face elevated risk because of social determinants of health.
A central feature of the announcement is its focus on policy-level interventions. The policy being evaluated can be local, state, tribal, federal, or set at an organizational level such as within schools, health systems, or other institutions. The expectation is that the proposed study will rigorously evaluate the impact of the selected policy on at least two overdose-related outcomes. Examples of qualifying outcomes include nonfatal overdose, fatal overdose, substance use disorders, levels of substance use, and initiation of substance use among youth. In practice, this means projects should be designed to capture multiple dimensions of harm and risk rather than relying on a single indicator.
The CDC also places heavy weight on implementation, not just outcomes. Applicants are expected to study how the policy is implemented, how implementation differs across settings, and how those differences affect whether the policy achieves its intended effects. This includes examining barriers and facilitators to implementation and assessing how implementation quality or reach may vary for populations facing structural disadvantage. The rationale is that a policy that looks effective on paper may produce mixed or inequitable results if it is adopted unevenly, enforced inconsistently, or interacts with local service availability and social conditions.
From an administrative standpoint, this is a discretionary grant (R01 mechanism) under the Department of Health and Human Services, Centers for Disease Control and Prevention, and is associated with CFDA 93.136. The funding opportunity number is RFA CE 24 012. The maximum award amount listed is $350,000, and CDC anticipates making about 2 awards under this announcement. The opportunity was created on August 30, 2023, with an original application due date of December 1, 2023 (applications were due by 11:59 pm ET).
Eligibility is broad and includes many types of organizations that could reasonably carry out policy evaluation research. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those categories as specified); for-profit organizations other than small businesses; small businesses; and other entities as allowed under the additional eligibility language. Overall, the grant is structured to support rigorous, policy-relevant evaluation work that can guide decision-makers toward interventions that reduce overdose while avoiding unintended harms and preventing the worsening of inequities.Apply for RFA CE 24 012
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Rigorous Evaluation of Policy-Level Interventions to Prevent Overdose (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
- This funding opportunity was created on Aug 30, 2023.
- Applicants must submit their applications by Dec 01, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Rigorous Evaluation of Policy-Level Interventions to Prevent Overdose (R01).
Which agency is offering this funding?
This is a research grant opportunity from the CDC Injury Center, under the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC).
What is the main purpose of this funding opportunity?
The purpose is to fund investigator-initiated studies that rigorously measure what overdose-related policies actually do in real-world settings, with a focus on generating strong, causal evidence about whether specific policies reduce drug use and overdose.
What kind of evidence is CDC looking for in funded studies?
The emphasis is on rigorous, causal evaluation of policy effects, rather than reporting only general or overall trends. The studies are expected to clarify whether observed changes can be attributed to the policy being evaluated.
Does the grant focus only on overall overdose outcomes?
No. The announcement stresses that it is not enough to report overall changes in overdose indicators. Applicants are expected to pay close attention to how impacts differ for groups that experience a disproportionate overdose burden or face elevated risk due to social determinants of health.
What is meant by "policy-level interventions" in this opportunity?
"Policy-level interventions" refers to policies that may be implemented at local, state, tribal, or federal levels, or at an organizational level (for example, within schools, health systems, or other institutions).
What types of policies can be evaluated?
The opportunity allows evaluation of policies set at multiple levels: local, state, tribal, federal, or organizational (such as policies within schools, health systems, or other institutions).
How many outcomes must a proposed study evaluate?
The proposed study is expected to rigorously evaluate the selected policy on at least two overdose-related outcomes.
What are examples of overdose-related outcomes that may qualify?
Examples listed include nonfatal overdose, fatal overdose, substance use disorders, levels of substance use, and initiation of substance use among youth.
Why does CDC require at least two overdose-related outcomes?
The intent is for projects to capture multiple dimensions of harm and risk, rather than relying on a single indicator.
Is implementation part of what must be studied?
Yes. CDC places heavy weight on implementation in addition to outcomes. Applicants are expected to study how the policy is implemented, how implementation differs across settings, and how those differences affect whether the policy achieves intended effects.
What implementation-related factors are applicants expected to examine?
The announcement highlights examining barriers and facilitators to implementation and assessing how implementation quality or reach may vary, including variation affecting populations facing structural disadvantage.
Does the opportunity address equity and disparities?
Yes. A core expectation is to examine whether the policy narrows or widens existing disparities in health and health care outcomes, especially for groups with a disproportionate overdose burden or increased risk tied to social determinants of health.
Why does CDC emphasize implementation differences across settings?
The announcement notes that a policy that looks effective on paper may produce mixed or inequitable results if it is adopted unevenly, enforced inconsistently, or interacts with local service availability and social conditions.
What grant mechanism is being used?
This opportunity uses the R01 mechanism and is described as a discretionary grant.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA 93.136.
What is the funding opportunity number?
The funding opportunity number is RFA CE 24 012.
What is the maximum award amount listed?
The maximum award amount listed is $350,000.
How many awards does CDC anticipate making?
CDC anticipates making about 2 awards under this announcement.
When was this opportunity created?
The opportunity was created on August 30, 2023.
What was the original application due date?
The original application due date was December 1, 2023, with applications due by 11:59 pm ET.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments and other tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofits with or without 501(c)(3) status (excluding institutions of higher education in those categories as specified)
- For-profit organizations other than small businesses
- Small businesses
- Other entities as allowed under the additional eligibility language
Can tribal governments or tribal organizations apply?
Yes. Federally recognized Native American tribal governments and other tribal organizations are listed as eligible applicants.
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses and also separately includes small businesses.
Are nonprofits eligible even if they do not have 501(c)(3) status?
Yes. The eligibility list includes nonprofits with or without 501(c)(3) status, with the noted exception that institutions of higher education are excluded in those categories as specified.
Are schools or higher education institutions eligible?
Yes. The list includes independent school districts, public and state-controlled institutions of higher education, and private institutions of higher education.
What is the overall focus of the supported research?
The grant is structured to support rigorous, policy-relevant evaluation that can guide decision-makers toward interventions that reduce overdose while avoiding unintended harms and preventing the worsening of inequities.
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